Potential therapeutic action of nitrite in sickle cell disease

Potential therapeutic action of nitrite in sickle cell disease

Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in hemolysis, which reduces nitric oxide (NO) bioavaila...

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Bibliographic Details
Main Authors: Nadeem Wajih, Swati Basu, Anuj Jailwala, Hee Won Kim, David Ostrowski, Andreas Perlegas, Crystal A. Bolden, Nancy L. Buechler, Mark T. Gladwin, David L. Caudell, Elaheh Rahbar, Martha A. Alexander-Miller, Vidula Vachharajani, Daniel B. Kim-Shapiro
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302525

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http://www.sciencedirect.com/science/article/pii/S2213231717302525

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