Robustness and fragility in immunosenescence.
We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associat...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-11-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC1664698?pdf=render |