Structural insights into 3Fe–4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450

Structural insights into 3Fe–4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450

Ferredoxins are small iron–sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe–4S ferredoxins are less studied mostly due to anaerobic requirements. Their complexes with cytochrome P450 redox partners have not been structurally characterized. In the present work, we...

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Bibliographic Details
Main Authors: Andrei Gilep, Tatsiana Varaksa, Sergey Bukhdruker, Anton Kavaleuski, Yury Ryzhykau, Sviatlana Smolskaya, Tatsiana Sushko, Kouhei Tsumoto, Irina Grabovec, Ivan Kapranov, Ivan Okhrimenko, Egor Marin, Mikhail Shevtsov, Alexey Mishin, Kirill Kovalev, Alexander Kuklin, Valentin Gordeliy, Leonid Kaluzhskiy, Oksana Gnedenko, Evgeniy Yablokov, Alexis Ivanov, Valentin Borshchevskiy, Natallia Strushkevich
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
3Fe–4S ferredoxins
cytochrome P450
crystal structure
protein–protein interactions
redox complex
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1100032/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.1100032/full

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