Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection.
A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00371/full |
| _version_ | 1819084251177418752 |
|---|---|
| author | Stephen J Turner Brendan E Russ Alice E Denton Lauren eHatton Hayley eCroom Matthew R Olson |
| author_facet | Stephen J Turner Brendan E Russ Alice E Denton Lauren eHatton Hayley eCroom Matthew R Olson |
| author_sort | Stephen J Turner |
| collection | DOAJ |
| description | A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage specific effector function in virus-specific CTL during both the effector and memory phases of immunity. |
| first_indexed | 2024-12-21T20:45:29Z |
| format | Article |
| id | doaj.art-6cc19abd9eb14033b09bac58fad3e682 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T20:45:29Z |
| publishDate | 2012-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6cc19abd9eb14033b09bac58fad3e6822022-12-21T18:50:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-12-01310.3389/fimmu.2012.0037139090Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection.Stephen J Turner0Brendan E Russ1Alice E Denton2Lauren eHatton3Hayley eCroom4Matthew R Olson5The University of MelbourneThe University of MelbourneCambridge UniversityThe University of MelbourneThe University of MelbourneThe University of MelbourneA cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage specific effector function in virus-specific CTL during both the effector and memory phases of immunity.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00371/fullTranscription FactorsepigeneticsCytotoxic T CellsHistone Modificationsmemory T cells. |
| spellingShingle | Stephen J Turner Brendan E Russ Alice E Denton Lauren eHatton Hayley eCroom Matthew R Olson Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. Frontiers in Immunology Transcription Factors epigenetics Cytotoxic T Cells Histone Modifications memory T cells. |
| title | Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. |
| title_full | Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. |
| title_fullStr | Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. |
| title_full_unstemmed | Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. |
| title_short | Defining the Molecular Blueprint that Drives CD8+ T cell Differentiation in response to infection. |
| title_sort | defining the molecular blueprint that drives cd8 t cell differentiation in response to infection |
| topic | Transcription Factors epigenetics Cytotoxic T Cells Histone Modifications memory T cells. |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00371/full |
| work_keys_str_mv | AT stephenjturner definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection AT brendaneruss definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection AT aliceedenton definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection AT laurenehatton definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection AT hayleyecroom definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection AT matthewrolson definingthemolecularblueprintthatdrivescd8tcelldifferentiationinresponsetoinfection |