Regulation of MMP-2 by IL-8 in Vascular Endothelial Cells: Probable Mechanism for Endothelial Dysfunction in Women with Preeclampsia

Regulation of MMP-2 by IL-8 in Vascular Endothelial Cells: Probable Mechanism for Endothelial Dysfunction in Women with Preeclampsia

Endothelial dysfunction (ED) in preeclampsia (PE) results from the convergence of oxidative stress, inflammation, and alterations in extracellular matrix components, affecting vascular tone and permeability. The molecular network leading to ED includes IL-8 and MMP-2. In vitro, IL-8 regulates the co...

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Bibliographic Details
Main Authors: Arturo Flores-Pliego, Aurora Espejel-Nuñez, Hector Borboa-Olivares, Sandra Berenice Parra-Hernández, Araceli Montoya-Estrada, Humberto González-Márquez, Ramón González-Camarena, Guadalupe Estrada-Gutierrez
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
preeclampsia
endothelial dysfunction
MMP-2
IL-8
Online Access:https://www.mdpi.com/1422-0067/25/1/122

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https://www.mdpi.com/1422-0067/25/1/122

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