Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells

Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells

Polyethyleneimine, poly-L-lysine, chitosan and some others cationic polymers have been thoroughly studied as nucleic acid delivery systems in gene therapy. However, the drug release from these systems proceeds at a very low rate due to extremely high binding between a carrier and gene material. To r...

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Bibliographic Details
Main Authors: Olga Osipova, Vladimir Sharoyko, Natalia Zashikhina, Natalya Zakharova, Tatiana Tennikova, Arto Urtti, Evgenia Korzhikova-Vlakh
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
amphiphilic polypeptides
self-assembly
nanoparticles
sirna delivery
vegf
gene silencing
Online Access:https://www.mdpi.com/1999-4923/12/1/39

Internet

https://www.mdpi.com/1999-4923/12/1/39

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