Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergi...

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Bibliographic Details
Main Authors: Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Chaigui granules
Traditional Chinese medicine
Antidepressant mechanism
Purine metabolism
Purinergic signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923001983

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http://www.sciencedirect.com/science/article/pii/S2095177923001983

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