Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergi...

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Detalles Bibliográficos
Main Authors: Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou
Formato: Artigo
Idioma:English
Publicado: Elsevier 2023-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Chaigui granules
Traditional Chinese medicine
Antidepressant mechanism
Purine metabolism
Purinergic signaling
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2095177923001983

Internet

http://www.sciencedirect.com/science/article/pii/S2095177923001983

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