Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy

Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy

Hypoxia is a key characteristic of the tumor microenvironment, too rarely considered during drug development due to the lack of a user-friendly method to culture naturally hypoxic 3D tumor models. In this study, we used soft lithography to engineer a microfluidic platform allowing the culture of up...

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Bibliographic Details
Main Authors: Elena Refet-Mollof, Ouafa Najyb, Rodin Chermat, Audrey Glory, Julie Lafontaine, Philip Wong, Thomas Gervais
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
hypoxia
microfluidics
spheroids
tumor microenvironment
CAIX
HIF1-α
Online Access:https://www.mdpi.com/2072-6694/13/16/4046

Internet

https://www.mdpi.com/2072-6694/13/16/4046

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