High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study

High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study

Abstract Background Renal ischemia/reperfusion injury is an unavoidable event in transplantation in which free radical-mediated injury determines release of pro-inflammatory cytokines and activation of innate immunity. In addition to their cholesterol-lowering action, statins have shown dose-depende...

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Bibliographic Details
Main Authors: Giacomo Cusumano, Edoardo Cola, Gionata Spagnoletti, Anna Severino, Simona Giubilato, Egidio Stigliano, Maria Emiliana Caristo, Gisella Vischini, Giovanna Liuzzo, Maria Paola Salerno, Filippo Crea, Jacopo Romagnoli
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Renal Replacement Therapy
Subjects:
Ischemia/reperfusion injury
Kidney transplantation
Atorvastatin
Oxidative stress
Inflammation
Online Access:https://doi.org/10.1186/s41100-023-00508-w

Internet

https://doi.org/10.1186/s41100-023-00508-w

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