Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins. After the evaluation of sigma receptor affinity and phar...

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Bibliographic Details
Main Authors: Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
pain
pruritus
itch
histamine H<sub>3</sub> receptor
sigma receptors
Online Access:https://www.mdpi.com/1424-8247/16/10/1481

Internet

https://www.mdpi.com/1424-8247/16/10/1481

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