Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice

Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice

Background Obesity is an established risk factor for hypertension. Although obesity‐induced gut barrier breach leads to the leakage of various microbiota‐derived products into host circulation and distal organs, the roles of microbiota in mediating the development of obesity‐associated adrenomedulla...

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Bibliographic Details
Main Authors: Hong Gao, Zhongmou Jin, Kechun Tang, Yudong Ji, Jorge Suarez, Jorge A. Suarez, Karina Cunha e Rocha, Dinghong Zhang, Wolfgang H. Dillmann, Sushil K. Mahata, Wei Ying
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
adrenomedullary inflammation
catecholamine
CRIg+ macrophage
microbial DNA
obesity‐induced hypertension
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024561

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.024561

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