Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2

Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2

ABSTRACT: The local lipid annulus, or “fingerprint”, of four SLC6 transporters (dDAT, hDAT, hSERT, and GlyT2) embedded in a complex neuronal membrane were compared and characterised using molecular dynamics. Our analysis included the development of new tools to improve membrane leaflet detection and...

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Bibliographic Details
Main Authors: Katie A. Wilson, Lily Wang, Yie Chang Lin, Megan L. O'Mara
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:BBA Advances
Subjects:
nNeuronal membrane
lLipid-protein interactions
SLC6 transport proteins
mMembrane transporters
mMolecular dynamics
mMembrane analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160321000090

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http://www.sciencedirect.com/science/article/pii/S2667160321000090

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