A preclinical model of cutaneous melanoma based on reconstructed human epidermis

Abstract Malignant melanoma is among the tumor entities with the highest increase of incidence worldwide. To elucidate melanoma progression and develop new effective therapies, rodent models are commonly used. While these do not adequately reflect human physiology, two-dimensional cell cultures lack...

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Bibliographic Details
Main Authors: Anna Leikeim, Maximiliane Wußmann, Freia F. Schmidt, Nuno G. B. Neto, Franziska Benz, Kendra Tiltmann, Corinna Junger, Michael G. Monaghan, Bastian Schilling, Florian K. Groeber-Becker
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19307-0