Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy

Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabrica...

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Bibliographic Details
Main Authors: Yuki Iizuka, Yoshiyuki Manabe, Kazuhiro Ooe, Atsushi Toyoshima, Xiaojie Yin, Hiromitsu Haba, Kazuya Kabayama, Koichi Fukase
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
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Online Access:https://www.mdpi.com/1422-0067/24/11/9593
Description
Summary:Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver <sup>211</sup>At (α-particle emitter) to the nuclei of cancer cells. The developed <sup>211</sup>At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery.
ISSN:1661-6596
1422-0067