Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabrica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9593 |
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| author | Yuki Iizuka Yoshiyuki Manabe Kazuhiro Ooe Atsushi Toyoshima Xiaojie Yin Hiromitsu Haba Kazuya Kabayama Koichi Fukase |
| author_facet | Yuki Iizuka Yoshiyuki Manabe Kazuhiro Ooe Atsushi Toyoshima Xiaojie Yin Hiromitsu Haba Kazuya Kabayama Koichi Fukase |
| author_sort | Yuki Iizuka |
| collection | DOAJ |
| description | Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver <sup>211</sup>At (α-particle emitter) to the nuclei of cancer cells. The developed <sup>211</sup>At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery. |
| first_indexed | 2024-03-11T03:04:40Z |
| format | Article |
| id | doaj.art-6cdaf234eee84cfab366971b453b6f0a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:04:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6cdaf234eee84cfab366971b453b6f0a2023-11-18T08:01:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411959310.3390/ijms24119593Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha TherapyYuki Iizuka0Yoshiyuki Manabe1Kazuhiro Ooe2Atsushi Toyoshima3Xiaojie Yin4Hiromitsu Haba5Kazuya Kabayama6Koichi Fukase7Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, JapanDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, JapanRadioisotope Research Center, Institute for Radiation Sciences, Osaka University, 2-4 Yamadaoka, Suita 565-0871, Osaka, JapanDivision of Science, Institute for Radiation Sciences, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, JapanRIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako 351-0198, Saitama, JapanRIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako 351-0198, Saitama, JapanDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, JapanDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, JapanTargeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver <sup>211</sup>At (α-particle emitter) to the nuclei of cancer cells. The developed <sup>211</sup>At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery.https://www.mdpi.com/1422-0067/24/11/9593targeted alpha therapy (TAT)drug delivery system (DDS)radiolabeled antibodyα-rayimagingnuclear localization signal (NLS) |
| spellingShingle | Yuki Iizuka Yoshiyuki Manabe Kazuhiro Ooe Atsushi Toyoshima Xiaojie Yin Hiromitsu Haba Kazuya Kabayama Koichi Fukase Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy International Journal of Molecular Sciences targeted alpha therapy (TAT) drug delivery system (DDS) radiolabeled antibody α-ray imaging nuclear localization signal (NLS) |
| title | Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy |
| title_full | Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy |
| title_fullStr | Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy |
| title_full_unstemmed | Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy |
| title_short | Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy |
| title_sort | exploring a nuclear selective radioisotope delivery system for efficient targeted alpha therapy |
| topic | targeted alpha therapy (TAT) drug delivery system (DDS) radiolabeled antibody α-ray imaging nuclear localization signal (NLS) |
| url | https://www.mdpi.com/1422-0067/24/11/9593 |
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