Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease

Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease

Intrastriatal embryonic ventral mesencephalon grafts have been shown to integrate, survive, and reinnervate the host striatum in clinical settings and in animal models of Parkinson’s disease. However, this ectopic location does not restore the physiological loops of the nigrostriatal pathway and pro...

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Bibliographic Details
Main Authors: Marine Droguerre, Sébastien Brot, Clément Vitrac, Marianne Benoit-Marand, Laure Belnoue, Maelig Patrigeon, Anaïs Lainé, Emile Béré, Mohamed Jaber, Afsaneh Gaillard
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
Parkinson’s disease
intranigral transplantation
L-DOPA
behavior
electrophysiological assessment
Online Access:https://www.mdpi.com/2073-4409/11/7/1191

Internet

https://www.mdpi.com/2073-4409/11/7/1191

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