VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome. However, the exact physiological role for most of these Type II TA systems are still unknown. Here, we have...

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Bibliographic Details
Main Authors: Arun Sharma, Gopinath Chattopadhyay, Pankaj Chopra, Munmun Bhasin, Chandrani Thakur, Sakshi Agarwal, Shahbaz Ahmed, Nagasuma Chandra, Raghavan Varadarajan, Ramandeep Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
toxin-antitoxin system
ribonuclease
drug tolerance
cross talk
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02037/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.02037/full

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