Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers

Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers

BackgroundChildren with B-cell acute lymphoblastic leukemia (B-ALL) have an immune imbalance that is marked by remodeling of the hematopoietic compartment, with effects on peripheral blood (PB). Although the bone marrow (BM) is the main maintenance site of malignancy, the frequency with which immune...

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Bibliographic Details
Main Authors: Maria Perpétuo Socorro Sampaio Carvalho, Fábio Magalhães-Gama, Bruna Pires Loiola, Juliana Costa Ferreira Neves, Nilberto Dias Araújo, Flavio Souza Silva, Claudio Lucas Santos Catão, Eliana Brasil Alves, João Paulo Diniz Pimentel, Maria Nazaré Saunier Barbosa, Nelson Abrahim Fraiji, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Allyson Guimarães Costa, Adriana Malheiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
childhood leukemia
cellular immunity
chemokines
cytokines
induction therapy
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1290505/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1290505/full

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