Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation. In order to achieve a goal of improving the water solubility of FB...

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Bibliographic Details
Main Authors: Ji-Hun An, Changjin Lim, Hyung Chul Ryu, Jae Sun Kim, Hyuk Min Kim, Alice Nguvoko Kiyonga, Minho Park, Young-Ger Suh, Gyu Hwan Park, Kiwon Jung
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Crystals
Subjects:
Febuxostat
cocrystal
solid-state NMR
solubility
active pharmaceutical ingredient
Online Access:https://www.mdpi.com/2073-4352/7/12/365

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https://www.mdpi.com/2073-4352/7/12/365

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