Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Several disease risk variants reside on non-coding regions of DNA, particularly in open chromatin regions of specific cell types. Identifying the cell types relevant to complex traits through the integration of chromatin accessibility data and genome-wide association studies (GWAS) data can help to...

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Bibliographic Details
Main Authors: Akash Chandra Das, Aidin Foroutan, Brian Qian, Nader Hosseini Naghavi, Kayvan Shabani, Parisa Shooshtari
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
open chromatin regions
GWAS
chromatin accessibility data
complex phenotypes
Online Access:https://www.mdpi.com/1422-0067/23/19/11456

Internet

https://www.mdpi.com/1422-0067/23/19/11456

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