USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction

USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction

Abstract TNF receptor-associated factor 6 (TRAF6)-BECN1 signaling axis plays a pivotal role in autophagy induction through ubiquitination of BECN1, thereby inducing lung cancer migration and invasion in response to toll-like receptor 4 (TLR4) stimulation. Herein, we provide novel molecular and cellu...

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Bibliographic Details
Main Authors: Mi-Jeong Kim, Yoon Min, Soo-Kyung Jeong, Juhee Son, Ji Young Kim, Ji Su Lee, Duk-Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04808-7

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https://doi.org/10.1038/s41419-022-04808-7

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