White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

Abstract Background To promote the development of effective therapies, there is an important need to characterize the full spectrum of neuropathological changes associated with Alzheimer’s disease. In line with this need, this study examined white matter abnormalities in individuals with early-onset...

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Bibliographic Details
Main Authors: Dorothee Schoemaker, Maria Clara Zanon Zotin, Kewei Chen, Kay C. Igwe, Clara Vila-Castelar, Jairo Martinez, Ana Baena, Joshua T. Fox-Fuller, Francisco Lopera, Eric M. Reiman, Adam M. Brickman, Yakeel T. Quiroz
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Autosomal-dominant Alzheimer’s disease
PSEN1
White matter hyperintensities
Cognition
Dementia
Cerebral microbleeds
Online Access:https://doi.org/10.1186/s13195-022-01030-7

Internet

https://doi.org/10.1186/s13195-022-01030-7

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