Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the control of CMV viraemia. Human leukocyte antig...

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Bibliographic Details
Main Authors: Meriem Attaf, Julia Roider, Amna Malik, Cristina Rius Rafael, Garry Dolton, Andrew J. Predergast, Alasdair Leslie, Thumbi Ndung'u, Henrik N. Kløverpris, Andrew K. Sewell, Philip J. Goulder
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
cytomegalovirus
T cell receptor
T cell receptor repertoire
superdominance
paediatric repertoire
repertoire dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01587/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01587/full

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