Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice

Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice

Even though human Campylobacter jejuni infections are progressively increasing worldwide, the underlying molecular mechanisms of pathogen-host-interactions are still not fully understood. We have recently shown that the secreted serine protease HtrA plays a key role in C. jejuni cellular invasion an...

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Bibliographic Details
Main Authors: Anna-Maria Schmidt, Ulrike Escher, Soraya Mousavi, Manja Boehm, Steffen Backert, Stefan Bereswill, Markus M. Heimesaat
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Campylobacter jejuni
secondary abiotic IL-10−/− mice
serine protease activity
high-temperature requirement A (HtrA)
host-pathogen-interaction
intestinal immunopathology
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00079/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00079/full

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