A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape

A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape

Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity, and transmissibility. A patient positive for HBV DNA and detectable but low-level HBsAg in parallel with anti-HBs suggested the presence of im...

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Bibliographic Details
Main Authors: Felix Lehmann, Heiko Slanina, Martin Roderfeld, Elke Roeb, Jonel Trebicka, John Ziebuhr, Wolfram H. Gerlich, Christian G. Schüttler, Bernhard Schlevogt, Dieter Glebe
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
hepatitis B virus
N-linked glycosylation
diagnostic escape
immune escape
Online Access:https://www.mdpi.com/1999-4915/15/4/838

Internet

https://www.mdpi.com/1999-4915/15/4/838

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