Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Abstract Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs. Tumors exceeding 500 counts of nonsynonymous single nucleotide variants (SNVs) were classified as...

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Bibliographic Details
Main Authors: Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Cancer Medicine
Subjects:
colorectal cancer
DNA polymerase epsilon gene
hypermutation
ultramutation
Online Access:https://doi.org/10.1002/cam4.2344

Internet

https://doi.org/10.1002/cam4.2344

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