DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics

DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics

Abstract Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often violated in complex and heterogeneous single-cell RNA sequencing (scRNA-seq) data. Using a graph convolution network, DeepVelo overcomes...

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Bibliographic Details
Main Authors: Haotian Cui, Hassaan Maan, Maria C. Vladoiu, Jiao Zhang, Michael D. Taylor, Bo Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Subjects:
RNA velocity
Single-cell RNA sequencing
Deep Learning
Development
Cancer
Online Access:https://doi.org/10.1186/s13059-023-03148-9

Internet

https://doi.org/10.1186/s13059-023-03148-9

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