miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Summary: Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a con...

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Bibliographic Details
Main Authors: Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure, Jyotsna Mishra, Jasmine George, Changliang Chen, Manoj K. Mishra, Andliena Tahiri, Wei Zhao, Bindu Nair, Yiling Lu, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Amadou K.S. Camara, Mingyu Liang, Janet S. Rader, Ramani Ramchandran, Ming You, Anil K. Sood, Vessela N. Kristensen, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315761

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http://www.sciencedirect.com/science/article/pii/S2211124719315761

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