Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration

Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration

Abstract Background Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expression is restricted to the tooth germ epithelium during the development of embryonic mouse teeth, has been demonstrated to play a crucial role in the regulat...

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Bibliographic Details
Main Authors: Zijie Wang, Chuying Chen, Jiayi Zhang, Jiangdie He, Lin Zhang, Jiayuan Wu, Zhihui Tian
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Stem Cell Research & Therapy
Subjects:
SCUBE3
Pulp–dentin regeneration
Odontoblastic differentiation
BMP2/Smad signalling
TGF/Smad signalling
Paracrine/autocrine
Online Access:https://doi.org/10.1186/s13287-023-03353-0

Internet

https://doi.org/10.1186/s13287-023-03353-0

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