Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling

BackgroundMajor depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors. Our previous study suggested that acute treatment with a novel curcumin derivative...

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Bibliographic Details
Main Authors: Jianxin Li, Ling Chen, Gaowen Li, Xiaojuan Chen, Sisi Hu, Liang Zheng, Victor Luria, Jinpeng Lv, Yindi Sun, Ying Xu, Yingcong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroscience
Subjects:
J147
antidepressant-like effects
5-HT1A
5-HT1B
cAMP/PKA
BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00701/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00701/full

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