Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19.

Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19.

Hox genes in species across the metazoa encode transcription factors (TFs) containing highly-conserved homeodomains that bind target DNA sequences to regulate batteries of developmental target genes. DNA-bound Hox proteins, together with other TF partners, induce an appropriate transcriptional respo...

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Bibliographic Details
Main Authors: Muriel Boube, Bruno Hudry, Clément Immarigeon, Yannick Carrier, Sandra Bernat-Fabre, Samir Merabet, Yacine Graba, Henri-Marc Bourbon, David L Cribbs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4006704?pdf=render

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http://europepmc.org/articles/PMC4006704?pdf=render

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