Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives

Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives

A series of 2,3-dihydroquinazolin-4(1<i>H</i>)-one derivatives (<b>3a</b>–<b>3m</b>) was screened for in vitro whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant (MDR) <i>Mycobacterium tuberculosis</i> (MTB)...

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Main Authors:	Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Wafa Hourani, Pran Kishore Deb, Melendhran Pillay, Bashaer Abu-Irmaileh, Yasser Bustanji, Sandeep Chandrashekharappa, Christophe Tratrat, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Pottathil Shinu, Michelyne Haroun, Mahmoud Kandeel, Abdulmalek Ahmed Balgoname, Rashmi Venugopala, Mohamed A. Morsy
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Antibiotics
Subjects:	dihydroquinazolin-4(1<i>H</i>)-ones anti-TB activity MTT assay molecular docking studies molecular dynamic simulations studies
Online Access:	https://www.mdpi.com/2079-6382/11/7/831

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