Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and structural approaches. Screening of 107,600 sm...

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Bibliographic Details
Main Authors: Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
JAK inhibitor
JAK2 V617F
myeloproliferative neoplasm
cytokine signaling
pseudokinase
Online Access:https://www.mdpi.com/1424-8247/16/1/75

Internet

https://www.mdpi.com/1424-8247/16/1/75

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