Paraquat Toxicogenetics: Strain-Related Reduction of Tyrosine Hydroxylase Staining in Substantia Nigra in Mice

Paraquat Toxicogenetics: Strain-Related Reduction of Tyrosine Hydroxylase Staining in Substantia Nigra in Mice

Paraquat (PQ) is a putative risk factor for the development of sporadic Parkinson’s disease. To model a possible genetic basis for individual differences in susceptibility to exposure to PQ, we recently examined the effects of paraquat on tyrosine hydroxylase (TH)-containing neurons in the substanti...

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Bibliographic Details
Main Authors: Carolina Torres-Rojas, Wenyuan Zhao, Daming Zhuang, James P. O’Callaghan, Lu Lu, Megan K. Mulligan, Robert W. Williams, Byron C. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Toxicology
Subjects:
tyrosine hydroxylase
sporadic Parkinson’s disease
stereology
BXD mice
forward genetic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2021.722518/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2021.722518/full

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