Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Immune checkpoint inhibitors (ICIs) have revolutionized the oncology field. However, a significant number of patients do not respond, at least partly due to the lack of preexisting anti-tumor T-cell immunity. Therefore, it is emergent to add an immune-priming step to improve efficacy. Here, we repor...

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Bibliographic Details
Main Authors: Chuan Jin, Arwa Ali, Alexandros Iskantar, Grammatiki Fotaki, Hai Wang, Magnus Essand, Alex Karlsson-Parra, Di Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Ilixadencel
pro-inflammatory allogeneic dendritic cells
αCTLA-4 therapy
tissue-residentCD8+ T cells
tumor-reactiveCD8+ T cells
tumor-specificCD8+ T cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2099642

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2099642

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