Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice

Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice

High-fat exposure leads to impaired intestinal barrier function by disrupting the function of intestinal stem cells (ISCs); however, the exact mechanism of this phenomenon is still not known. We hypothesize that high concentrations of deoxycholic acid (DCA) in response to a high-fat diet (HFD) affec...

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Bibliographic Details
Main Authors: Leheng Liu, Jingxian Xu, Xianjun Xu, Tiancheng Mao, Wenlu Niu, Xiaowan Wu, Lungen Lu, Hui Zhou
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat diet
deoxycholic acid
aryl hydrocarbon receptor
intestinal stem cells
kynurenine
indoleamine 2,3-dioxygenase 1
Online Access:https://www.mdpi.com/1422-0067/23/24/15578

Internet

https://www.mdpi.com/1422-0067/23/24/15578

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