Impact of Additional Chromosomal Aberrations on the Disease Progression of Chronic Myelogenous Leukemia

Impact of Additional Chromosomal Aberrations on the Disease Progression of Chronic Myelogenous Leukemia

The emergence of additional chromosomal abnormalities (ACAs) in Philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia (CML), is considered to be a feature of disease evolution. However, their frequency of incidence, impact on prognosis and treatment response effect in CML is not conclus...

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Bibliographic Details
Main Authors: Ramachandran Krishna Chandran, Narayanan Geetha, Kunnathur Murugesan Sakthivel, Raveendran Suresh Kumar, Kumarapillai Mohanan Nair Jagathnath Krishna, Hariharan Sreedharan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Oncology
Subjects:
additional chromosomal aberrations
variant Ph translocation
Spectral Karyotyping
blast crisis
fluorescent in situ hybridization
Philadelphia Chromosome
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00088/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00088/full

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