Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice

Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice

Age-related macular degeneration (AMD) is the major cause of blindness in the elderly in developed countries and its prevalence is increasing with the aging population. AMD initially affects the retinal pigment epithelium (RPE) and gradually leads to secondary photoreceptor degeneration. Recent stud...

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Bibliographic Details
Main Authors: Meng Zhang, Yi Chu, Joseph Mowery, Brandon Konkel, Susana Galli, Alexander C. Theos, Nady Golestaneh
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
RPE
AMD
Retinal degeneration
PGC-1α
High-fat diet
Mitochondria
Autophagy
Online Access:http://dmm.biologists.org/content/11/9/dmm032698

Internet

http://dmm.biologists.org/content/11/9/dmm032698

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