Multicomponent synthesis, cytotoxicity, and computational studies of novel imidazopyridazine-based N-phenylbenzamides

Multicomponent synthesis, cytotoxicity, and computational studies of novel imidazopyridazine-based N-phenylbenzamides

A one-pot multicomponent synthesis and application of new imidazopyridazine based N-phenylbenzamides is described. An atom-economical method involving dimethyl phthalate, substituted anilines, and pyridazine-4,5-diamine provided the desired compounds in 120–150 min with 80–85% yield. The reaction wa...

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Bibliographic Details
Main Authors: M. Shaheer Malik, Reem A. Alsantali, Abdullah Y.A. Alzahrani, Qazi Mohammad Sajid Jamal, Essam M. Hussein, Khalid A. Alfaidi, Munirah M. Al-Rooqi, Rami J. Obaid, Meshari A. Alsharif, Syed Farooq Adil, Rabab S. Jassas, Ziad Moussa, Saleh A. Ahmed
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Saudi Chemical Society
Subjects:
Imidazopyridazine
N-Phenylbenzamide
Multicomponent reaction
Cytotoxicity
Computational studies
Online Access:http://www.sciencedirect.com/science/article/pii/S131961032200031X

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http://www.sciencedirect.com/science/article/pii/S131961032200031X

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