Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles.

Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles.

BACKGROUND:Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. These motors crosslink and slide microtubules in the spindle. Kinesin-5 motors are phosphorylated at a conserved site by Cyclin-dependent kinase 1 (Cdk1) during m...

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Bibliographic Details
Main Authors: Julie Cahu, Aurelien Olichon, Christian Hentrich, Henry Schek, Jovana Drinjakovic, Cunjie Zhang, Amanda Doherty-Kirby, Gilles Lajoie, Thomas Surrey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2592692?pdf=render

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http://europepmc.org/articles/PMC2592692?pdf=render

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