Obtaining HBV core protein VLPs carrying SARS-CoV-2 nucleocapsid conserved fragments as vaccine candidates

Obtaining HBV core protein VLPs carrying SARS-CoV-2 nucleocapsid conserved fragments as vaccine candidates

Abstract The Hepatitis B core antigen (HBcAg) has been used as a carrier of several heterologous protein fragments based on its capacity to form virus-like particles (VLPs) and to activate innate and adaptive immune responses. In the present work, two chimeric proteins were designed as potential pan...

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Bibliographic Details
Main Authors: Yadira Lobaina, Alexis Musacchio, Panchao Ai, Rong Chen, Edith Suzarte, Glay Chinea, Miaohong Zhang, Zhiqiang Zhou, Yaqin Lan, Ricardo Silva, Gerardo Guillén, Ke Yang, Wen Li, Yasser Perera, Lisset Hermida
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
Subjects:
HBcAg
Nucleocapsid
SARS-CoV-2
Chimeric proteins
Pancorona vaccine
Intranasal
Online Access:https://doi.org/10.1186/s12985-024-02583-9

Internet

https://doi.org/10.1186/s12985-024-02583-9

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