The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis
IntroductionMultiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The pathophysiology of MS is complex and is said to be influenced by multiple environmental determinants, including diet. We and others have previously demonstrated how consumption of bovine m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202006/full |
| _version_ | 1797783935339462656 |
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| author | Rittika Chunder Thorsten Heider Stefanie Kuerten |
| author_facet | Rittika Chunder Thorsten Heider Stefanie Kuerten |
| author_sort | Rittika Chunder |
| collection | DOAJ |
| description | IntroductionMultiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The pathophysiology of MS is complex and is said to be influenced by multiple environmental determinants, including diet. We and others have previously demonstrated how consumption of bovine milk can aggravate disease severity in MS patients, which can be explained by molecular mimicry between milk antigens and those expressed within the CNS. In this study we set out to identify alternatives to drinking cow milk which might be less detrimental to MS patients who have a genetic predisposition towards developing antibody titers against bovine milk antigens that cross-react with CNS antigens.MethodsTo this end, we screened 35 patients with MS and 20 healthy controls for their IgG reactivity against an array of animal-sourced milk, plant-based alternatives as well as individual antigens from bovine milk.ResultsWe demonstrate that MS patients have a significantly higher IgG response to animal-sourced milk, especially cow milk, in comparison to healthy donors. We also show that the reactivity to cow milk in MS patients can be attributed to reactivity against different bovine milk antigens. Finally, our correlation data indicate the co-existence of antibodies to individual bovine milk antigens and their corresponding cross-reactive CNS antigens.DiscussionTaken together, we suggest screening of blood from MS patients for antibodies against different types of milk and milk antigens in order to establish a personalized diet regimen. |
| first_indexed | 2024-03-13T00:32:56Z |
| format | Article |
| id | doaj.art-6d0cb02d15a84a49b75cab5eebc6fa15 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T00:32:56Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6d0cb02d15a84a49b75cab5eebc6fa152023-07-10T09:37:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12020061202006The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosisRittika Chunder0Thorsten Heider1Stefanie Kuerten2Institute of Neuroanatomy, Medical Faculty, University of Bonn, Bonn, GermanyClinic for Neurology, Klinikum St. Marien Amberg, Amberg, GermanyInstitute of Neuroanatomy, Medical Faculty, University of Bonn, Bonn, GermanyIntroductionMultiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The pathophysiology of MS is complex and is said to be influenced by multiple environmental determinants, including diet. We and others have previously demonstrated how consumption of bovine milk can aggravate disease severity in MS patients, which can be explained by molecular mimicry between milk antigens and those expressed within the CNS. In this study we set out to identify alternatives to drinking cow milk which might be less detrimental to MS patients who have a genetic predisposition towards developing antibody titers against bovine milk antigens that cross-react with CNS antigens.MethodsTo this end, we screened 35 patients with MS and 20 healthy controls for their IgG reactivity against an array of animal-sourced milk, plant-based alternatives as well as individual antigens from bovine milk.ResultsWe demonstrate that MS patients have a significantly higher IgG response to animal-sourced milk, especially cow milk, in comparison to healthy donors. We also show that the reactivity to cow milk in MS patients can be attributed to reactivity against different bovine milk antigens. Finally, our correlation data indicate the co-existence of antibodies to individual bovine milk antigens and their corresponding cross-reactive CNS antigens.DiscussionTaken together, we suggest screening of blood from MS patients for antibodies against different types of milk and milk antigens in order to establish a personalized diet regimen.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202006/fullanimal-sourced milkcross-reactivitymilk proteinsmultiple sclerosismyelin antigensplant-based milk |
| spellingShingle | Rittika Chunder Thorsten Heider Stefanie Kuerten The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis Frontiers in Immunology animal-sourced milk cross-reactivity milk proteins multiple sclerosis myelin antigens plant-based milk |
| title | The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis |
| title_full | The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis |
| title_fullStr | The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis |
| title_full_unstemmed | The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis |
| title_short | The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis |
| title_sort | prevalence of igg antibodies against milk and milk antigens in patients with multiple sclerosis |
| topic | animal-sourced milk cross-reactivity milk proteins multiple sclerosis myelin antigens plant-based milk |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202006/full |
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