5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling
A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2024/1/M1779 |
| _version_ | 1797239865645989888 |
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| author | Laura Giraldo-Arroyave Andrés F. Yepes Wilson Cardona-Galeano |
| author_facet | Laura Giraldo-Arroyave Andrés F. Yepes Wilson Cardona-Galeano |
| author_sort | Laura Giraldo-Arroyave |
| collection | DOAJ |
| description | A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations taken together indicated that the novel hybrids have a strong possibility to advance to further biological studies. |
| first_indexed | 2024-04-24T17:58:20Z |
| format | Article |
| id | doaj.art-6d0dd1d67d1d4d57a89bd452ececdb54 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-04-24T17:58:20Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-6d0dd1d67d1d4d57a89bd452ececdb542024-03-27T13:56:38ZengMDPI AGMolbank1422-85992024-02-0120241M177910.3390/M17795-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness ModelingLaura Giraldo-Arroyave0Andrés F. Yepes1Wilson Cardona-Galeano2Chemistry of Colombian Plants Group, Institute of Chemistry, Faculty of Exact and Natural Sciences, Universidad de Antioquia, UdeA, Calle 70 No. 52–21, A.A 1226, Medellín 050010, ColombiaChemistry of Colombian Plants Group, Institute of Chemistry, Faculty of Exact and Natural Sciences, Universidad de Antioquia, UdeA, Calle 70 No. 52–21, A.A 1226, Medellín 050010, ColombiaChemistry of Colombian Plants Group, Institute of Chemistry, Faculty of Exact and Natural Sciences, Universidad de Antioquia, UdeA, Calle 70 No. 52–21, A.A 1226, Medellín 050010, ColombiaA series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations taken together indicated that the novel hybrids have a strong possibility to advance to further biological studies.https://www.mdpi.com/1422-8599/2024/1/M17795-FUcoumarinchromonehybrid compoundsclick chemistrydrug-likeness modeling |
| spellingShingle | Laura Giraldo-Arroyave Andrés F. Yepes Wilson Cardona-Galeano 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling Molbank 5-FU coumarin chromone hybrid compounds click chemistry drug-likeness modeling |
| title | 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling |
| title_full | 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling |
| title_fullStr | 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling |
| title_full_unstemmed | 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling |
| title_short | 5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling |
| title_sort | 5 fluorouracil coumarin and 5 fluorouracil chromone hybrids synthesis and drug likeness modeling |
| topic | 5-FU coumarin chromone hybrid compounds click chemistry drug-likeness modeling |
| url | https://www.mdpi.com/1422-8599/2024/1/M1779 |
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