Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure

Abstract The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter transcript which codes for a putatively secreted protei...

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Bibliographic Details
Main Authors: Joan Roig-Soriano, Cristina Sánchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdés, Carmela R. Abraham, Assumpció Bosch, Francesc Ventura, Miguel Chillón
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-31117-6