Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography

Abstract Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each tryptophan residue. Here, we describe the use of...

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Bibliographic Details
Main Authors: Alexander J. Lander, Laura Domínguez Mercado, Xuefei Li, Irshad Maajid Taily, Brandon L. Findlay, Yi Jin, Louis Y. P. Luk
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-00953-y