Identification of residues in ethylene oxide sterilized hard gelatin capsule shells by gas chromatography-mass spectrometry and development of a simple gas chromatography-flame ionization detector method for the determination of residues
ABSTRACT: Four toxic residues in gelatin capsule shells after ethylene oxide (EO) sterilization were identified by gas chromatography-mass spectrometer (GC-MS) and they were ethylene oxide, 2-chloroethanol, acetaldehyde, and 1,4-dioxane. The generation pathway and mechanism of the 2-chloroethanol, a...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-11-01
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Series: | Journal of Chromatography Open |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391722000317 |