Identification of residues in ethylene oxide sterilized hard gelatin capsule shells by gas chromatography-mass spectrometry and development of a simple gas chromatography-flame ionization detector method for the determination of residues

Identification of residues in ethylene oxide sterilized hard gelatin capsule shells by gas chromatography-mass spectrometry and development of a simple gas chromatography-flame ionization detector method for the determination of residues

ABSTRACT: Four toxic residues in gelatin capsule shells after ethylene oxide (EO) sterilization were identified by gas chromatography-mass spectrometer (GC-MS) and they were ethylene oxide, 2-chloroethanol, acetaldehyde, and 1,4-dioxane. The generation pathway and mechanism of the 2-chloroethanol, a...

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Bibliographic Details
Main Authors: Dandan Wang, Aijing Zhang, Wenxu Guo, Bingqi Zhu, Hui Yu, Yue Chen
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Chromatography Open
Subjects:
Hard gelatin capsule shells
Ethylene oxide sterilization
GC-MS
GC-FID
Identification
Determination
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391722000317

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http://www.sciencedirect.com/science/article/pii/S2772391722000317

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