Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells

Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells

Chronic liver injury may result in hepatic fibrosis, which can progress to cirrhosis and eventually liver failure. There are no drugs that are specifically approved for treating hepatic fibrosis. The natural product honokiol (HNK), a bioactive compound extracted from <i>Magnolia grandiflora<...

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Bibliographic Details
Main Authors: Seita Kataoka, Atsushi Umemura, Keiichiro Okuda, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshihiro Kanbara, Jack L. Arbiser, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
hepatic fibrosis
stellate cell
honokiol
autophagy
Online Access:https://www.mdpi.com/1422-0067/22/24/13354

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https://www.mdpi.com/1422-0067/22/24/13354

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