c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role...

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Bibliographic Details
Main Authors: Chimera L. Lyle, Mostafa Belghasem, Vipul C. Chitalia
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
angiogenesis
tumors
ubiquitination
proteasomal degradation
c-Cbl
RTK
non-RTK
VEGFR
FGFR
PDGFR
EGFR
c-Met
Wnt signaling
β–catenin
PLCγ1
Online Access:https://www.mdpi.com/2073-4409/8/5/498

Internet

https://www.mdpi.com/2073-4409/8/5/498

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