c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis
Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/5/498 |
| _version_ | 1797706116800446464 |
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| author | Chimera L. Lyle Mostafa Belghasem Vipul C. Chitalia |
| author_facet | Chimera L. Lyle Mostafa Belghasem Vipul C. Chitalia |
| author_sort | Chimera L. Lyle |
| collection | DOAJ |
| description | Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role of c-Cbl in angiogenesis and human solid organ tumors. The combination of its unique structure, modular function, and ability to channelize cues from a rich network of signaling cascades, empowers c-Cbl to assume a central role in these disease models. This review consolidates the structural and functional insights based on recent studies that highlight c-Cbl as a target with tantalizing therapeutic potential in various models of angiogenesis and tumorigenesis. |
| first_indexed | 2024-03-12T05:47:30Z |
| format | Article |
| id | doaj.art-6d2086f5df004a668eb30208c0b6b3dd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T05:47:30Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6d2086f5df004a668eb30208c0b6b3dd2023-09-03T05:33:01ZengMDPI AGCells2073-44092019-05-018549810.3390/cells8050498cells8050498c-Cbl: An Important Regulator and a Target in Angiogenesis and TumorigenesisChimera L. Lyle0Mostafa Belghasem1Vipul C. Chitalia2Department of Medicine, Boston University Medical Center, Boston, MA 02118, USADepartment of Pathology and Laboratory Medicine, Boston University Medical Center, Boston, MA 02118, USADepartment of Medicine, Boston University Medical Center, Boston, MA 02118, USACasitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role of c-Cbl in angiogenesis and human solid organ tumors. The combination of its unique structure, modular function, and ability to channelize cues from a rich network of signaling cascades, empowers c-Cbl to assume a central role in these disease models. This review consolidates the structural and functional insights based on recent studies that highlight c-Cbl as a target with tantalizing therapeutic potential in various models of angiogenesis and tumorigenesis.https://www.mdpi.com/2073-4409/8/5/498angiogenesistumorsubiquitinationproteasomal degradationc-CblRTKnon-RTKVEGFRFGFRPDGFREGFRc-MetWnt signalingβ–cateninPLCγ1 |
| spellingShingle | Chimera L. Lyle Mostafa Belghasem Vipul C. Chitalia c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis Cells angiogenesis tumors ubiquitination proteasomal degradation c-Cbl RTK non-RTK VEGFR FGFR PDGFR EGFR c-Met Wnt signaling β–catenin PLCγ1 |
| title | c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis |
| title_full | c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis |
| title_fullStr | c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis |
| title_full_unstemmed | c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis |
| title_short | c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis |
| title_sort | c cbl an important regulator and a target in angiogenesis and tumorigenesis |
| topic | angiogenesis tumors ubiquitination proteasomal degradation c-Cbl RTK non-RTK VEGFR FGFR PDGFR EGFR c-Met Wnt signaling β–catenin PLCγ1 |
| url | https://www.mdpi.com/2073-4409/8/5/498 |
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