Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT

Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT

Background: Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% of patients. The role of B cells in rheumatoid arthritis pathogenesis is well recognised and is supported by the clinical effica...

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Bibliographic Details
Main Authors: Frances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Michele Bombardieri, Christopher John, Hasan Rizvi, Louise Warren, Joanna Peel, Liliane Fossati-Jimack, Rebecca E Hands, Giovanni Giorli, Felice Rivellese, Juan D Cañete, Peter C Taylor, Peter Sasieni, João E Fonseca, Ernest Choy, Costantino Pitzalis
Format: Article
Language:English
Published: NIHR Journals Library 2022-08-01
Series:Efficacy and Mechanism Evaluation
Subjects:
rheumatoid arthritis
biologic
synovium
synovial tissue
histology
ultrasound
rituximab
tocilizumab
Online Access:https://doi.org/10.3310/GOPL1729

Internet

https://doi.org/10.3310/GOPL1729

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